Endocrine Abstracts

We conducted a longitudinal study on 95 children presented to pediatric clinic with short stature. Children were classified to low IGF1 (IGF1SDS <-1) (n=25) and normal IGF1 (IGF1SDS >-1) (n=70) and treated with human GH (0.03: 0.05 mg/kg/day) for 2 years. Anthropometrics data (HtSDS, difference from mid-parental height SDS (MPHSD), BMISDS, bone age and IGF1 level were studied for 2 years.Results: At presentation, the age, bone a...

The Relationship between Precocious/Early Puberty and Obesity with Metabolic Abnormalities: A Comprehensive ReviewIntroduction: The impact of pubertal timing on the development of obesity and metabolic abnormalities has been the subject of extensive research with variable outcomes. Objective: We systematically reviewed studies (Medline, Pubmed, Google scholar, and Web of Science) 2000 until March 2023 evaluating the relation betwee...

This study aimed to explore the prevalence of distinct Metabolic Syndrome (MetS) components and plasma AIP among obese children and adolescents, and to evaluate their anthropometric measures in comparison to their parents, thereby considering genetic and environmental influences.Methodology: Anthropometric and biochemical profiles of 91 randomly selected obese children and young adolescents (mean age: 10.5&pm;2.7 years) were meticulously analyzed. This c...

Introduction: The contribution of reproductive factors to breast cancer (BC) susceptibility requires further investigation. This study aims to explore the potential link between early puberty (menarche) and the risk of breast cancer in women.Aim: This study systematically reviews research conducted between 2000 and March 2023, aiming to evaluate the association between early/precocious puberty and the incidence of BC.Methods: A com...

Introduction: Celiac disease is an autoimmune disorder related to gluten ingestion in genetically predisposed individuals. Its clinical expression is polymorphic, rendering it a true systemic disease, and its management is based on a gluten-free diet (GFD). Autoimmune endocrinopathies are disorders affecting endocrine glands such as the thyroid or adrenal glands, also stemming from autoimmune reactions with complex pathophysiological mechanisms involving environmental, genetic...

Introduction: This review aims to systematically analyze and summarize the findings from research articles regarding the potential short-term and long-term side effects of L-thyroxine therapy in children and adolescents. The selection criteria for the studies included their focus on the negative effects of thyroxine therapy related to thyroid health, cognitive function, cardiovascular health, bone health, and cancer risk in pediatric populations. Results...

Pituitary microadenomas in children and adolescents are relatively rare, accounting for a small percentage of pediatric endocrine disorders. These benign tumors often present a diagnostic challenge due to their subtle and variable clinical manifestations at this young age. We present clinical and lab data of 5 children with pituitary microadenoma. Case 1: A 12-year-old female with a history of short stature and slow growth velocity was diagnosed with a small pituitary microade...

Background: Hypothyroidism is a common disorder, with a prevalence of approximately 5% and incidence of approximately 250/100,000 per year in the adult population, but both prevalence and incidence keep raising. Refractory hypothyroidism is defined by persistent TSH increase despite the administration of supra physiological weight-based dose of levothyroxine, which is usually >1.9ug/kg/d in patients with primary hypothyroidism.Aim of the Work: To com...

Introduction: Diabetes is a disease that can slowly be. Among its complications, erectile dysfunction can appear. Be careful, these problems can be warning signs. These problems can be warning signs, especially cardiovascular, but they also have significant psychological retention.Materials and methods: Prospective study on 37 diabetic patients collegiate in the department of Endocrinology CHU Hedi Chaker Sfax Tunisia. All patients are assessed for erect...

Introduction: Osteoporosis and diabetes are two chronic diseases with increasing prevalences, particularly among elderly. Their coexistence results in socio-economic burdens. Clinical and paraclinical assessment for fracture risk among diabetic eldery patients are necessary to implement in clinical practice. Appropriate tools shoud to be determined and tested.Objective: To assess comorbidities and fracture risk in elderly patients having type 2 diabetes ...